All-Laser Lasik, also called "IntraLasik", "iLASIK", and "zLASIK" is exactly like traditional conventional or custom wavefront Lasik, except the corneal flap is created with a femtosecond laser microkeratome rather than a mechanical microkeratome with a metal blade. The IntraLasik name comes from a combination of the name of a femtosecond laser manufacturer, Intralase, and Lasik.

All-Laser Lasik may be performed with conventional laser ablation or wavefront-guided custom Lasik laser ablation.

There are several advantages to All-Laser Lasik that can make All-Laser Lasik more predictable and safer than traditional Lasik with a mechanical microkeratome, however there are limitations and a unique set of concerns that need to be evaluated.

Advantages include more precise positioning of the flap, more accurate thickness of the flap, more even thickness of the flap throughout, and a lower probability of intraoperative complications such as buttonhole flaps, thin/thick flaps, or epithelial defect. Recent studies have shown All-Laser Lasik to be more favorable than Lasik with a mechanical microkeratome in providing vision with better contrast sensitivity.

Some patients, but not all, experience a short period of increased corneal edema with All-Laser Lasik. This slight swelling can cause vision to be blurry, but the swelling normally resolves with healing. Occasionally an All-Laser Lasik patient will experience some photosensitivity. All these issues usually resolve during the normal Lasik six-month healing process, however additional eye drop medication may be required.

All-Laser Lasik is an option for nearly all who decide to have refractive surgery with a corneal flap, but All-Laser Lasik may be a requirement for individuals with preexisting epithelial defects, large pupils, thin corneas, poor contrast sensitivity, or other physiological reasons that indicate the greater accuracy and safety of All-Laser Lasik is required.